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The G protein-coupled inwardly rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand -stimulated G protein-coupledgirk receptors (GPCRs). [1][2] GPCRs in turn release activated G-protein ...

G-protein-gated inwardly rectifying K + (GIRK) channels play a key role in maintaining resting membrane potential, cell excitability and inhibitory neurotransmissgirkion.

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.

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